Search This Blog

Monday, November 14, 2011

Can we predict montelukast treatment failure in step-down therapy for controlled asthma?

Although many physicians and patients want to replace low dose inhaled steroids with montelukast in controlled patients with mild asthma, there are insufficient data to predict montelukast failure. A study by Drummond et al (J Asthma 2011 Oct 27 [Epub ahead of print]) provides a piece of the puzzle. Using the 165 participants in the Leukotriene or Corticosteroid or Corticosteroid-Salmeterol Study (LOCCS) trial who were stepped down from low-dose ICS to montelukast, the authors attempted to predict the risk of montelukast treatment failure during step-down. Characteristics independently associated with montelukast treatment failure included early asthma onset (<10 years), need for steroid burst in the last year, and low pre-bronchodilator FEV1. They constructed a montelukast failure index that may prove to be helpful for clinical practice, but it needs further validation.


  1. I have a medical supply retailer that is interested in supporting your blog. We can offer regular guest posts on current events that relate to your website or support you financially in exchange for a simple text link. Here a few examples of blogs we write for below:

    "Senior Living Rockies Blog"
    "Medical Noise"
    "A Patriotic Nurse"
    "Medical Collage"

    Could you send pricing on what would it take to get listed under a new category like ""Online Supporters"" in your sidebar or a footer link?

    My client, JRS Medical, is not just a retailer, they are also involved in reaching out to those less fortunate... from the victims of Haiti's earthquake to those in need through the Samaritan's Purse program. They also provide crutches for the amputee victims from Haiti's earthquake.

    I look forward to hearing back from you and working together.

    David Patterson
    Social Media Coordinator for JRS Medical